We investigated how RCI001 can help mice with primary Sjögren syndrome. Eight 12-week-old NOD.B10-H2b mice were divided into two groups, one receiving RCI001 and the other a control treatment.
After one week, we noted significant improvements in eye health and tear secretion for the RCI group. They also showed reduced levels of inflammatory markers compared to those treated with the control. Overall, RCI001 proved to effectively reduce inflammation and oxidative stress, suggesting a promising therapeutic option for this autoimmune disease.
Read More
8
Potential of cyclotides in immunomodulation
Plant-derived Cyclotides in Immunomodulation and their Therapeutic Potential.
We delved into the potential of plant-derived cyclotides, particularly focusing on a modified version of kalata B1, known as [T20K], for autoimmune disorders such as multiple sclerosis. Our investigations revealed that daily doses in mice led to reduced cytokine levels and minimal inflammation, suggesting a promising alternative to traditional immunosuppressive drugs. While the results are encouraging, further research is needed to fully assess the effectiveness of cyclotides in human applications. Overall, cyclotides appear to hold significant promise in the realm of immune modulation.
Read More
Most Useful Reviews
9
Quick recovery support
4 people found this helpful
This is an excellent natural immunity stimulator! I’ve taken it several times when unwell and felt better within days. I even gave half a tablet to my 5-year-old child, who coped well. I'd recommend it without hesitation; you won't regret it!
Read More
9
Quick relief
1 people found this helpful
Upon receiving the product, my husband and I used it immediately for our herpes outbreaks linked to an autoimmune disorder. I was healed in two days, he took three days. I will reorder for immune support.
Read More
9
Effective for herpes
28 people found this helpful
This product is an impressive mix! Amino Acid Lysine, Garlic, Echinacea, Vitamin C, and Propolis are just what I need for immune support. It's beneficial for those with the herpes virus; Lysine effectively inhibits it. However, if you have an autoimmune disorder, you should avoid this supplement and just take Lysine without echinacea or garlic. Thank you!
We investigated how RCI001 can help mice with primary Sjögren syndrome. Eight 12-week-old NOD.B10-H2b mice were divided into two groups, one receiving RCI001 and the other a control treatment.
After one week, we noted significant improvements in eye health and tear secretion for the RCI group. They also showed reduced levels of inflammatory markers compared to those treated with the control. Overall, RCI001 proved to effectively reduce inflammation and oxidative stress, suggesting a promising therapeutic option for this autoimmune disease.
Read More
8
Potential of cyclotides in immunomodulation
Plant-derived Cyclotides in Immunomodulation and their Therapeutic Potential.
We delved into the potential of plant-derived cyclotides, particularly focusing on a modified version of kalata B1, known as [T20K], for autoimmune disorders such as multiple sclerosis. Our investigations revealed that daily doses in mice led to reduced cytokine levels and minimal inflammation, suggesting a promising alternative to traditional immunosuppressive drugs. While the results are encouraging, further research is needed to fully assess the effectiveness of cyclotides in human applications. Overall, cyclotides appear to hold significant promise in the realm of immune modulation.
Read More
User Reviews
USERS' SCORE
Good
Based on 24 Reviews
8.1
All Reviews
Positive Reviews
Negative Reviews
9
Quick recovery support
4 people found this helpful
This is an excellent natural immunity stimulator! I’ve taken it several times when unwell and felt better within days. I even gave half a tablet to my 5-year-old child, who coped well. I'd recommend it without hesitation; you won't regret it!
Read More
9
Quick relief
1 people found this helpful
Upon receiving the product, my husband and I used it immediately for our herpes outbreaks linked to an autoimmune disorder. I was healed in two days, he took three days. I will reorder for immune support.
Read More
9
Effective for herpes
28 people found this helpful
This product is an impressive mix! Amino Acid Lysine, Garlic, Echinacea, Vitamin C, and Propolis are just what I need for immune support. It's beneficial for those with the herpes virus; Lysine effectively inhibits it. However, if you have an autoimmune disorder, you should avoid this supplement and just take Lysine without echinacea or garlic. Thank you!
Read More
7.5
Cold symptom relief
18 people found this helpful
This immune formula is excellent! I've purchased it twice and plan to buy it again. It helps tremendously at the first signs of a cold. I took three capsules before bed, and by morning, I felt fine. It contains lysine, vitamin C, calcium, propolis, and echinacea extract.
Read More
9
Herpes treatment success
14 people found this helpful
I’ve dealt with cold sores for years and was sceptical about Lysine, but it worked wonders! After just two days of taking six pills daily, the pain and blisters vanished. Previously, blisters lasted eight days. I will continue to take Lysine and give it to my child for sniffles. Amazing results!
An autoimmune disorder occurs when the body's immune system mistakenly attacks its own healthy cells and tissues, believing them to be foreign invaders, such as bacteria or viruses. This reaction can lead to inflammation, tissue damage, and impaired function of the affected organs. There are over 80 known autoimmune diseases, including rheumatoid arthritis, lupus, multiple sclerosis, and type 1 diabetes, each with its own specific symptoms and treatment options. The exact cause of these disorders is still unclear, but a combination of genetic, environmental, and hormonal factors is believed to play a role in their development.
Diagnosis of autoimmune disorders often involves a combination of physical examinations, assessment of symptoms, blood tests, and imaging studies to evaluate organ involvement. Treatment typically focuses on managing symptoms and controlling the immune response using medications such as corticosteroids, immunosuppressants, and biologics. In addition to medication, lifestyle modifications, such as stress management and a balanced diet, can be beneficial in managing symptoms. If you suspect you have an autoimmune condition, it's important to consult a healthcare professional for proper evaluation and tailored treatment options.
L-Lysine is an essential amino acid that plays a crucial role in many bodily functions. Unlike some amino acids that can be synthesized by the body, L-Lysine must be obtained through diet or supplementation. It is particularly important for protein synthesis, hormone production, and the absorption of calcium. Good dietary sources of L-Lysine include meat, fish, dairy products, eggs, and certain plant sources such as beans and legumes. Athletes and individuals looking to support muscle recovery and growth often consider L-Lysine supplements.
In addition to its role in enhancing muscle recovery, L-Lysine is also often touted for its potential benefits in supporting immune function and combating cold sores caused by the herpes simplex virus. Some studies suggest that L-Lysine may help reduce the frequency and severity of these outbreaks. However, it’s always advisable to consult with a healthcare professional before starting any new supplement to determine the appropriate dosage and ensure it aligns with your health needs.
Based on user reviews, the timeframe to see results from this supplement can vary quite a bit, especially when considering different conditions like autoimmune disorders or symptoms related to herpes. Some users report significant improvements within just a couple of days. For instance, one reviewer noted that they experienced healing from herpes outbreaks in as little as two days after starting the supplement Read Review. Another reviewer mentioned relief from cold symptoms after taking the product for only two days Read Review.
On the other hand, there are mixed experiences concerning effectiveness for individuals specifically dealing with autoimmune disorders. While some users noticed fewer flare-ups and improved immune function over the weeks Read Review, others expressed dissatisfaction, suggesting that the supplement did not provide the anticipated results, even over extended periods of use Read Review. Therefore, while many users see results in about 2-3 days, it’s essential to remain patient, as responses to supplements can be highly individual and may vary significantly.
The scientific research indicates that certain supplements show promise for managing autoimmune disorders. For instance, a study focused on modified plant-derived cyclotides, specifically a variant known as [T20K], highlighted their potential in reducing cytokine levels and inflammation in mice with autoimmune conditions like multiple sclerosis. Although the results are promising, further investigation is necessary to evaluate the effectiveness of these cyclotides in human subjects ([1]).
Additionally, research on RCI001 demonstrated significant positive effects in mouse models of primary Sjögren syndrome. Mice treated with RCI001 exhibited improvements in eye health and tear production and experienced lower inflammation levels compared to control groups. These findings suggest that RCI001 may be a viable therapeutic option for autoimmune diseases, although more clinical trials are needed to confirm its efficacy in humans ([2]). Overall, while certain supplements have displayed potential in preclinical studies, additional research is essential to establish their effectiveness for human autoimmune disorder treatment.
Based on user reviews, many individuals have reported notable improvements in their symptoms after using this supplement. For example, one user highlighted how their husband's herpes outbreak resolved in just three days, while they personally found relief within two days Read Review. Several others experienced rapid relief from cold symptoms, with one reviewer stating that they felt completely normal by the morning after taking a few capsules at bedtime Read Review. Another user remarked that they had successfully avoided cold illnesses for an entire winter season since starting the supplement Read Review.
Conversely, some users dealing with autoimmune disorders expressed mixed results; while a few found their symptoms improved or flares reduced significantly Read Review, others reported no notable effects or even adverse experiences Read Review. This array of experiences reinforces that while many users report effective relief within days to weeks, individual results can vary widely. It's important for potential users to consider their specific health conditions and response to supplements as they explore their options.
Based on user reviews, there is a varied perspective regarding the effectiveness of combining this supplement with other products for managing autoimmune disorders. Some users have reported significant improvements in their symptoms, expressing that their autoimmune disorder flared less frequently after using the supplement Read Review. Another user noted that since taking lysine, they haven’t experienced as many flare-ups during winter months Read Review. However, caution is advised, as other users indicate potential issues. One user mentioned adverse effects linked to the presence of licorice root in the supplement, such as prolonged bleeding Read Review.
Additionally, some reviews recommend against using this specific formula with ingredients like echinacea or garlic if one has an autoimmune disorder, suggesting that it may be more beneficial to stick with isolated ingredients, such as lysine alone, for safety and efficacy Read Review. Overall, while there is potential for positive outcomes when combining this supplement with other supplements, user experiences indicate that results can greatly differ, and individual considerations should always be made.
Users reported varying experiences regarding the appropriate dose of L Lysine for treating autoimmune disorders. Some individuals noted significant relief from herpes symptoms when taking higher doses, such as six pills daily, experiencing improvements within days Read Review. Conversely, others emphasized that for those with autoimmune disorders, it's better to avoid combination supplements that include additional ingredients like echinacea or garlic, and stick to plain L Lysine, suggesting that excessive dosages or mixes could lead to adverse effects Read Review.
A common sentiment from users was that to effectively address an autoimmune disorder, one may require a much higher dosage than typically found in standard products; some argued that to achieve antiviral effects, doses should range from 4-6 grams daily, as they found the typical dosage insufficient Read Review. Thus, while experiences vary, a tailored approach which considers individual health needs and a preferable range of 4-6 grams seems to be suggested for those managing autoimmune conditions alongside viral outbreaks.
9
Quick relief
1 people found this helpful
Upon receiving the product, my husband and I used it immediately for our herpes outbreaks linked to an autoimmune disorder. I was healed in two days, he took three days. I will reorder for immune support.
9
Herpes treatment success
14 people found this helpful
I’ve dealt with cold sores for years and was sceptical about Lysine, but it worked wonders! After just two days of taking six pills daily, the pain and blisters vanished. Previously, blisters lasted eight days. I will continue to take Lysine and give it to my child for sniffles. Amazing results!
7.5
Consistent effectiveness
2 people found this helpful
These vitamins produced excellent results for my husband and me. After taking them, we experienced fewer illnesses, and my autoimmune disorder flared less frequently.
2
No effect noticed
2 people found this helpful
I did not observe any effect. The lysine content of 1500 mg is based on three tablets, meaning only 500 mg per tablet, which is insufficient for antiviral effects. To treat an autoimmune disorder, one needs 4-6 grams daily. I did not notice this remedy helping with colds.
7.5
Cold symptom relief
18 people found this helpful
This immune formula is excellent! I've purchased it twice and plan to buy it again. It helps tremendously at the first signs of a cold. I took three capsules before bed, and by morning, I felt fine. It contains lysine, vitamin C, calcium, propolis, and echinacea extract.
7.5
Reduced sickness frequency
2 people found this helpful
To my surprise, since taking this lysine, I haven't fallen ill as often during winter, and my autoimmune disorder hasn't flared up either!
6
Effective but caution
2 people found this helpful
I initially took this to manage my autoimmune disorder and it worked swiftly, clearing an infection in two days. However, the presence of licorice root caused unexpected side effects, such as prolonged bleeding. I'll opt for a version without licorice next time.
9
Supportive blend
1 people found this helpful
I ordered these to support my immunity during autumn. Having taken them previously without falling ill, I appreciate the beneficial ingredients like Vitamin C and lysine.
7.5
Effective immune boost
6 people found this helpful
This product is a fantastic mix! It supports immunity well with Amino Acid Lysine, Garlic, Echinacea, Vitamin C, and Propolis. It effectively controls the herpes virus, as Lysine is similar to arginine, which the virus uses to multiply. People with an autoimmune disorder should avoid this mix and use just Lysine. Thanks!
8
Potential of cyclotides in immunomodulation
Plant-derived Cyclotides in Immunomodulation and their Therapeutic Potential.
We delved into the potential of plant-derived cyclotides, particularly focusing on a modified version of kalata B1, known as [T20K], for autoimmune disorders such as multiple sclerosis. Our investigations revealed that daily doses in mice led to reduced cytokine levels and minimal inflammation, suggesting a promising alternative to traditional immunosuppressive drugs. While the results are encouraging, further research is needed to fully assess the effectiveness of cyclotides in human applications. Overall, cyclotides appear to hold significant promise in the realm of immune modulation.
9
RCI001 shows promise for Sjögren syndrome
Efficacy of RCI001 as a Therapeutic Candidate in a Primary Sjögren Syndrome Mouse Model.
We investigated how RCI001 can help mice with primary Sjögren syndrome. Eight 12-week-old NOD.B10-H2b mice were divided into two groups, one receiving RCI001 and the other a control treatment.
After one week, we noted significant improvements in eye health and tear secretion for the RCI group. They also showed reduced levels of inflammatory markers compared to those treated with the control. Overall, RCI001 proved to effectively reduce inflammation and oxidative stress, suggesting a promising therapeutic option for this autoimmune disease.
References
Mishra R, Agarwal P, Sharma A, Mittal M, Gulati P, et al. Plant-derived Cyclotides in Immunomodulation and their Therapeutic Potential. Protein Pept Lett. 2025. 10.2174/0109298665364479250214101422
Kang H, Jung YH, Moon J, Ryu JS, Yoon CH, et al. Efficacy of RCI001 as a Therapeutic Candidate in a Primary Sjögren Syndrome Mouse Model. Cornea. 2025;44:226. 10.1097/ICO.0000000000003696